Most arboviral infections are asymptomatic. Clinical disease ranges from mild febrile illness to severe encephalitis. For the purpose of surveillance and reporting, based on their clinical presentation, arboviral disease cases are often categorized into two primary groups: neuroinvasive disease and nonneuroinvasive disease.
A clinically compatible case of arboviral disease is defined as follows:
Neuroinvasive disease: Meningitis, encephalitis, acute flaccid paralysis, or other acute signs of central or peripheral neurologic dysfunction, as documented by a physician, AND Absence of a more likely clinical explanation.
Non-neuroinvasive disease: Fever (chills) as reported by the patient or a health-care provider, AND Absence of neuroinvasive disease, AND Absence of a more likely clinical explanation.
A case that meets the above clinical criteria for neuroinvasive disease and has confirmatory lab evidence
A case that meets the above clinical criteria for neuroinvasive disease and has supportive lab evidence
A case that meets the above clinical criteria for non-neuroinvasive disease and has confirmatory lab evidence
A case that meets the above clinical criteria for non-neuroinvasive disease and has supportive lab evidence
NOTE: Zika virus disease had been added to the list of subtypes for Arboviral diseases, neuroinvasive and non-neuroinvasive based on the implicit inclusion of this subtype in the Arboviral diseases category as referenced in CSTE Position Statement 14-ID-04. Office of Management and Budget approval of the NNDSS Revision, 0920-0728 on January 21, 2016, authorized CDC to receive case notifications for Arboviral diseases, including Zika virus disease.
Related Case Definitions:
Date Posted: