Perinatal Hepatitis B (PHB)

2017 Case Definition

CSTE Position Statement Number: 16-ID-06

Clinical Criteria

Perinatal HBV infection in a child ≤ 24 months of age may range from asymptomatic to fulminant hepatitis.

Laboratory Criteria

Laboratory evidence of HBV infection in a child consists of one or more of the following:

• positive HBsAg test (only if at least 4 weeks after last dose of Hep B vaccine)
• positive HBeAg test, or
• detectable HBV DNA

Epidemiologic Linkage

Born to a HBV-infected mother.

Case Classification

Probable

Child born in the US and positive for HBsAg at ≥ 1 month of age and ≤ 24 months of age OR positive for HBeAg or HBV DNA ≥9 months of age and ≤ 24 months of age, but whose mother’s hepatitis B status is unknown (i.e. epidemiologic linkage not present).

Confirmed

Child born in the US to a HBV-infected mother and positive for HBsAg at ≥ 1 month of age and ≤ 24 months of age OR positive for HBeAg or HBV DNA ≥9 months of age and ≤ 24 months of age.

Date Posted: January 13, 2017

Updated: August 19, 2020