Staphylococcus aureus can produce a variety of syndromes with clinical manifestations including skin and soft tissue infections, empyema, bloodstream infection, pneumonia, osteomyelitis, septic arthritis, endocarditis, sepsis, and meningitis. S. aureus may also colonize individuals who remain asymptomatic. The most frequent site of S. aureus colonization is the nares.
Confirmed: A case of vancomycin-intermediate or vancomycin-resistant S. aureus that is laboratory-confirmed (MIC = 4–8 µg/ml for VISA and MIC ≥ 16 µg/ml for VRSA).
| Criterion | Confirmed VISA | Confirmed VRSA |
|---|---|---|
| Laboratory Findings | ||
| Isolation of S. aureus from any body site | N | N |
| Resistance of the S. aureus isolate to vancomycin (Minimum Inhibitory Concentration [MIC] ≥ 16 µg/ml) † | N | |
| Intermediate resistance of the S. aureus isolate to vancomycin (Minimum Inhibitory Concentration [MIC] 4–8 µg/ml) † | N | |
N = This criterion in conjunction with all other “N” criteria in the same column is required to report a case.
† = detected and defined according to Clinical and Laboratory Standards Institute approved standards and recommendations (CLSI 2006).
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